• Derek K Chu, Christopher M Hillis, Darryl P Leong, Sonia S Anand, and Deborah M Siegal.
• From McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.
• Ann. Intern. Med. 2017 Aug 1; 167 (3): 170-180.

BackgroundPatients with essential thrombocythemia (ET) are at high risk for both thrombosis and hemorrhage.PurposeTo evaluate the risks and benefits of antithrombotic therapy in adults with ET.Data SourcesMultiple databases, including MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials, through 4 March 2017.Study SelectionRandomized and observational studies of antiplatelet or anticoagulant therapy, published in any language and reporting thrombotic or hemorrhagic events.Data ExtractionTwo reviewers independently extracted data, assessed risk of bias, and graded certainty of evidence.Data SynthesisNo relevant randomized trials were identified. Twenty-four observational studies (18 comparative and 6 single-group) involving 6153 patients followed for 31 711 patient-years were reviewed; most were deemed to have high risk of bias. Most patients receiving antiplatelet therapy (3613 of 4527 [80%]) received low-dose aspirin (50 to 150 mg/d); 914 (20%) received high-dose aspirin (300 to 600 mg/d), dipyridamole, or other agents. Overall, findings were inconsistent and imprecise. The reported incidence rates of thrombosis, any bleeding, and major bleeding without antiplatelet therapy ranged from 5 to 110 (median, 20), from 3 to 39 (median, 8), and from 2 to 53 (median, 6) cases per 1000 patient-years, respectively. The reported relative risks for thrombosis, any bleeding, and major bleeding with antiplatelet therapy compared with none ranged from 0.26 to 3.48 (median, 0.74), from 0.48 to 11.04 (median, 1.95), and from 0.48 to 5.17 (median, 1.30), respectively. Certainty of evidence was rated low or very low for all outcomes.LimitationNo randomized trials, no extractable data on anticoagulants, lack of uniform bleeding definitions, and systematic reporting of outcomes.ConclusionAvailable evidence about the risk-benefit ratio of antiplatelet therapy in adults with ET is highly uncertain.Primary Funding SourceRegional Medical Associates. (PROSPERO: CRD42015027051).

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