• Ting-Ting Cai, Xiao-Long Ye, Hui-Juan Yong, Bin Song, Xiao-Ling Zheng, Bo-Ta Cui, Fa-Ming Zhang, Yi-Bing Lu, Heng Miao, and Da-Fa Ding.
• Department of Endocrinology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing.
• Medicine (Baltimore). 2018 Dec 1; 97 (50): e13543.

RationaleFecal microbiota transplantation (FMT) has been used in a wide variety of diseases. In this article, we reported a 46-year-old female with diabetic neuropathy (DN) achieved remission by the treatment of FMT.Patient ConcernsThe patient with an 8-year history of diabetes and hypertension was admitted to hospital due to sensitive pain of her right thigh and poor blood glucose control. The traditional hypoglycemic and analgesic treatment were useless to her symptoms.DiagnosisDiabetic-induced neuropathy was considered.InterventionsThis patient received twice FMTs for 3 months.OutcomesAfter twice FMTs, the clinical response of patient was pleasant. The glycemic control was improved, with a remarkable relief of the symptoms of painful DN in particular. No obvious adverse effects were observed during the FMTs and follow-up observation-testing.LessonsWe proposed that FMT could be a promising treatment in patients with diabetes or diabetes-related complications like DN. FMT also appeared to be definitely safer and more tolerable than the pharmacologic treatment in patients with DN.

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