• Xiang Li, Feng Wang, Yufan Wang, Shuai Sun, and Hongyu Yang.
• Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province.
• Medicine (Baltimore). 2018 Dec 1; 97 (51): e13691.

RationaleMucoepidermoid carcinoma (MEC) is the most common primary salivary gland malignancy. Ectopic MEC can occur in any part of the body, however, only 2% to 4% of MEC could be detected in the jaw, which is named intraosseous mucoepidermoid carcinoma (IMC). IMC is usually a low-grade carcinoma. Uni- or multilocular radiographic lesions should be differential diagnosed with ameloblastoma, odontogenic cysts, and glandular odontogenic cyst (GOC). Radical surgery may prefer for a favorable prognosis. Whereas IMC can recur long after the operation, a long-term follow-up system should be implemented. Owing to its rarity and controversial issues, we report a case report and review the literature to discuss its clinical features, treatments, radiological, and histological characteristics.Patient ConcernsThe patient presented with a 2-month history of mild pain in the lower left posterior jaw without history of surgery or trauma to the mandible.DiagnosesRoutine postoperative pathology showed that the mass was consistent with a mandibular mucoepidermoid carcinoma.InterventionRadical surgery and digital mandibular reconstruction were performed.OutcomePostoperative imaging showed that the height of the mandible and the symmetry of the mandible were satisfactory. The patient was also satisfied with her appearance. Follow-up has been established.LessonsEffective surgical treatment allows patients to have a favorable prognosis. A long-term follow-up system should be practiced, because local recurrences and regional metastasis could happen even after decades.

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