• Medicine · Dec 2018

    Case Reports

    Long-term hormonal therapy resulting in breast cancer in female-to-male transsexual: Case report.

    • Inka Treskova, Ondrej Hes, and Vlastimil Bursa.
    • Department of Plastic Surgery.
    • Medicine (Baltimore). 2018 Dec 1; 97 (52): e13653.

    RationaleTestosterone is important for the development of secondary sexual characteristics in female-to-male transsexuals. On the contrary, it can increase the risk of breast cancer.Patient ConcernsWe present a rare case of breast cancer in female-to-male transsexual patient after long-term hormonal therapy.DiagnosisBreast cancer in female-to-male transsexual patient.InterventionsThe patient underwent mastectomy and chemotherapy.OutcomesThe patient had local recurrence of the disease and he underwent re-excision, radiotherapy and the tamoxifen treatment. After this treatment, the patient is in the remission from the disease.LessonsBreast cancer in transsexuals appears to be rare. However, there is a potential risk that testosterone exposure can increase the risk of developing breast cancer by the stimulation of breast tissue. There is limited published literature on the risk of breast cancer in transsexual patients.

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