• Transl Res · Jul 2018

    Review

    NF-κB pathways in the development and progression of colorectal cancer.

    • Meera Patel, Paul G Horgan, Donald C McMillan, and Joanne Edwards.
    • Unit of Experimental Therapeutics, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, United Kingdom; Academic Unit of Surgery, School of Medicine, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom. Electronic address: meerapatel@doctors.org.uk.
    • Transl Res. 2018 Jul 1; 197: 43-56.

    AbstractNuclear factor-κB (NF-κB) has been widely implicated in the development and progression of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes such as cell proliferation, apoptosis, angiogenesis, and metastasis. The role of NF-κB in CRC is complex, owed to the cross talk with other signaling pathways. Although there is sufficient evidence gained from cell lines and animal models that NF-κB is involved in cancer-related processes, because of a lack of studies in human tissue, the clinical evidence of its importance is limited in patients with CRC. This review summarizes evidence relating to how NF-κB is involved in the development and progression of CRC and comments on future work to be carried out.Copyright © 2018 Elsevier Inc. All rights reserved.

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