• Jie Huang, Dong Tang, Yan Xu, Xuna Wang, Chuanwen Yu, and Yang Dong.
• Department of Radiology, The Second Affiliated Hospital of Dalian Medical University, Dalian.
• Medicine (Baltimore). 2019 Feb 1; 98 (7): e14465e14465.

RationalePrimary cranial vault lymphoma (PCVL) is an extremely rare extranodal lymphoma in the skull. This case study investigates the clinical features, so as to improve the understanding of the diagnosis and therapy.Patient ConcernsA 31-year-old male presented painful scalp mass at the site of 1-month-old head trauma.DiagnosisThe final diagnosis was plasma cell lymphoma, which is a rare subtype of diffuse large B-cell lymphoma based on biopsy and immunohistochemistry findings.InterventionsThe patient received total tumor resection in combination with chemotherapy OUTCOMES:: The patient survived without signs of systemic dissemination for 12 months after surgery at the time of last follow-up.LessonsTrauma may be one of the factors that induce PCVL. The final diagnosis of PCVL depends on pathology and immunohistochemistry findings. A combined treatment of surgery, chemotherapy, and radiotherapy can achieve favorable outcomes.

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