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Case Reports
Reversible acute adrenal insufficiency caused by fluconazole in a critically ill patient.
- S G Santhana Krishnan and R K Cobbs.
- Department of Internal Medicine, Metropolitan Hospital Center, New York, USA. sgskrishnan@hotmail.com
- Postgrad Med J. 2006 Sep 1; 82 (971): e23.
AbstractA 38 year old man with history of obstructive sleep apnea and polycythaemia presented with hypercapnic respiratory failure that required intubation. He developed fever with infiltrates on chest radiography that required empiric antifungal therapy with fluconazole along with broad spectrum antibiotics. He developed acute adrenal insufficiency that recovered after fluconazole was stopped. It is believed that this complication of adrenal suppression attributable to fluconazole is underrecognised and it may be prudent to monitor all critically ill patients who are given fluconazole for this complication.
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