• Internal medicine · Jan 2015

    Case Reports

    Bortezomib in type I cryoglobulinemic vasculitis: are we acting too late?

    • Giuseppe A Ramirez, Corrado Campochiaro, Chiara Salmaggi, Gaia Pagliula, Teresa D'Aliberti, Magda Marcatti, Moreno Tresoldi, and Luisa Praderio.
    • Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, 2) Università Vita-Salute San Raffaele, Italy.
    • Intern. Med. 2015 Jan 1; 54 (9): 111911231119-23.

    AbstractType II and type III cryoglobulinemic vasculitis (CV) are characterized by a deranged immune function due to concomitant chronic infections or rheumatic disorders. Conversely, type I CV is caused by plasma cell dyscrasia. Bortezomib is a proteasome inhibitor that is largely employed as a first-line treatment for multiple myeloma. The use of bortezomib in cases of monoclonal gammopathy of undetermined significance (MGUS)-related refractory type I CV has been reported in only four patients. In the current report, we discuss the efficacy of bortezomib treatment in a patient with type I CV, with a focus on the suitability and early application of this drug.

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