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Review Case Reports
Light-Chain Deposition Disease Successfully Treated with Bortezomib in an Elderly Patient: A Case Report and Review of the Literature.
- Yukihiro Wada, Masayuki Iyoda, Tomohiro Saito, Noriko Arai-Nunota, Ken Iseri, Eiko Tomita, Misa Ikeda, Yutaka Yamaguchi, and Takanori Shibata.
- Division of Nephrology, Department of Medicine, Showa University School of Medicine, Japan.
- Intern. Med. 2015 Jan 1; 54 (22): 2893-8.
AbstractWe herein report the case of an elderly patient with light-chain deposition disease (LCDD) successfully treated with bortezomib. An 83-year-old woman was admitted because of nephrotic syndrome. She was diagnosed to have monoclonal gammopathy of undetermined significance (IgG-κ type) and LCDD, on the basis of serum and urinary immunoelectrophoresis and renal biopsy. She responded to a modified regimen of bortezomib-based chemotherapy with disappearance of proteinuria without any adverse effects. According to a literature review of 16 cases, including the present case, bortezomib-based chemotherapy appears to be a convincing strategy for the treatment of LCDD even in elderly patients.
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