• J Coll Physicians Surg Pak · Apr 2014

    Cancer Antigen-125 as a marker of ascites in patients with liver cirrhosis.

    • Muhammad Omar Qureshi, Faisal Saud Dar, and Nasir Khokhar.
    • Department of Gastroenterology, Shifa International Hospital, Islamabad.
    • J Coll Physicians Surg Pak. 2014 Apr 1; 24 (4): 232-5.

    ObjectiveTo evaluate the correlation between Cancer Antigen-25 (CA-125) levels with the amount of ascites in patients with liver cirrhosis.Study DesignObservational, analytical study.Place And Duration Of StudyShifa International Hospital, Islamabad, from March 2012 to February 2013.MethodologyA total of 130 patients with liver cirrhosis (with and without ascites) had serum CA-125 levels measured. The amount of ascites was classified according to physical examination and ultrasound (USG) findings. CA-125 levels were compared and correlated with amount of ascites.ResultsMajority of patients (57%) had hepatitis C virus and 60% were in class Child Pugh C. There was moderate correlation between amount of ascites and CA-125 levels (r = 0.642, p < 0.001) with significant raised levels of CA-125 in patients with ascites (p < 0.001).ConclusionThere was a moderate correlation between CA-125 levels and presence and amount of ascites.

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