• Yelda Dere, Aysegu Aksoy Altinboga, Kaan Bal, Aylin Calli, Murat Ermete, and Aysegul Akder Sari.
• Department of Pathology, Mugla Sitki Kocman University, Faculty of Medicine, Mugla, Turkey.
• J Coll Physicians Surg Pak. 2017 Apr 1; 27 (4): 213-217.

ObjectiveTo determine the relationship between biochemical recurrence and other histopathological factors in prostate cancer.Study DesignAnalytical study.Place And Duration Of StudyPathology and Urology Departments, Izmir Ataturk Training and Research Hospital, between 2001 - 2013.Methodology117 cases diagnosed with prostatic adenocarcinoma and treated by radical prostatectomy were reviewed retrospectively for histopathological features; whereas, other prognostic findings were noted. PSA levels and many other histopathological parameters were assessed in order to put forth their effect on biochemical recurrence.ResultsPSA level (p<0.001), tumor volume (p<0.001), Gleason score (p<0.001), extraprostatic extension (p<0.001), perineural invasion (p<0.001), ganglion involvement (p=0.040), vascular invasion (p<0.001), positive surgical margins (p<0.001), presence of tertiary pattern (p=0.004) and the involvement of the seminal vesicles (p<0.001) were found to be statistically related to the pathological stage. Age, perineural invasion, high grade tertiary pattern, intraluminal mucin, collagenous micronodules and foamy cytoplasmic changes were unrelated to recurrence.ConclusionHistopathological features can be helpful in predicting prognosis in prostatic adenocarcinomas. However some of the histopathological factors such as intraluminal mucin and foamy cytoplasmic changes may not reflect high recurrence.

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