• Jing Xu, Xiaofeng Hao, Bingwen Lu, Jing Ming, Xiaoyu Li, Yixin Qi, and Like Xie.
• Department of Ophthalmology, Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
• Medicine (Baltimore). 2019 Jun 1; 98 (25): e16044e16044.

BackgroundArtemisinin was discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. It is derived from extracts of sweet wormwood (Artemisia annua) and are well established for the treatment of malaria. Recently, artemisinin has been shown that it might have therapeutic value for several other diseases. The purpose of this review is to assess the efficacy of artemisinin as a treatment for macular edema associated with retinal vein occlusion.Methods And AnalysisA systematic literature search will be performed in all available databases to quantitatively review eligible studies and identify all relevant data. We will include randomized controlled trials assessing efficacy of artemisinin as a treatment for macular edema associated with retinal vein occlusion. The methodological qualities, including the risk of bias, will be evaluated using the Cochrane risk of bias assessment tool, while confidence in the cumulative evidence will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.Ethics And DisseminationEthical approval is not required, as this study is based on the review of published research. This review will be published in a peer-reviewed journal and disseminated both electronically and in print.Prospero Registration NumberThe protocol for this systematic review has been registered on PROSPERO under the number CRD42019131408.

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