• Eur. J. Clin. Invest. · Jan 2017

    IL-1B rs16944 polymorphism is related to septic shock and death.

    • María Ángeles Jiménez-Sousa, Luz M Medrano, Pilar Liu, Raquel Almansa, Amanda Fernández-Rodríguez, Esther Gómez-Sánchez, Lucía Rico, María Heredia-Rodríguez, Estefanía Gómez-Pesquera, Eduardo Tamayo, and Salvador Resino.
    • Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain.
    • Eur. J. Clin. Invest. 2017 Jan 1; 47 (1): 53-62.

    BackgroundIL-1β is a primary mediator of systemic inflammatory response syndrome (SIRS) and it may lead to shock septic. Our aim was to analyse whether IL-1B rs16944 polymorphism is associated with the onset of septic shock and death after major surgery.Materials And MethodsWe performed a case-control study on 467 patients who underwent major cardiac or abdominal surgery. Of them, 205 patients developed septic shock (cases, SS group) and 262 patients developed SIRS (controls, SIRS group). The primary outcome variables were the development of septic shock and death within 90 days after diagnosis of septic shock. The IL-1B rs16944 polymorphism was genotyped by Sequenom's MassARRAY platform. The association analysis was performed under a recessive genetic model (AA vs. GG/GC).ResultsThe frequency of septic shock was higher in patients with IL-1B rs16944 AA genotype than in patients with IL-1B rs16944 GG/AG genotype when all patients were taken into account (63·6% vs. 41·8%; P = 0·006), cardiac surgery (52·2% vs. 33·3%; P = 0·072) and abdominal surgery (76·2% vs. 50·2%; P = 0·023). However, the IL-1B rs16944 AA genotype was only associated with higher likelihood of septic shock in the analysis of all population [adjusted odds ratio (aOR) = 2·26 (95%CI = 1·03; 4·97; P = 0·042], but not when it was stratified by cardiac surgery (P = 0·175) or abdominal surgery (P = 0·467). Similarly, IL-1B rs16944 AA genotype was also associated with higher likelihood of septic shock-related death in all population [aOR = 2·67 (95%CI = 1·07; 4·97); P = 0·035].ConclusionsIL-1B rs16944 AA genotype seems to be related to the onset of septic shock and death in patients who underwent major surgery.© 2016 Stichting European Society for Clinical Investigation Journal Foundation.

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