European journal of clinical investigation
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Eur. J. Clin. Invest. · Jan 2017
Review Meta AnalysisEffect of statins on serum vitamin D concentrations: a systematic review and meta-analysis.
We conducted a systematic review and meta-analysis to assess the effects of statin therapy on serum vitamin D concentrations. ⋯ This meta-analysis was inconclusive on the effects of statins on vitamin D, with conflicting directions of the effects from interventional and observational studies. The suggested favourable effects from RCTs need to be confirmed in larger studies with extended follow-up in order to determine the possible health benefits.
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Eur. J. Clin. Invest. · Jan 2017
Pentraxin 3 in patients with severe sepsis or shock: the ALBIOS trial.
The long pentraxin PTX3 is a key component of the humoral arm of innate immunity related to sepsis severity and mortality. We evaluated the clinical and prognostic significance of circulating PTX3 in the largest cohort ever reported of patients with severe sepsis or septic shock. ⋯ In severe sepsis and septic shock, early high PTX3 predict subsequent new organ failures, while a smaller drop in circulating PTX3 over time predicts an increased risk of death. Patients with septic shock show lower levels of PTX3 when assigned to albumin than to crystalloids.
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Eur. J. Clin. Invest. · Jan 2017
Antibiotic resistance in healthcare-related and nosocomial spontaneous bacterial peritonitis.
Spontaneous bacterial peritonitis (SBP) can be life threatening in patients with liver cirrhosis. In contrast to community-acquired SBP, no standard treatment has been established for healthcare-related and nosocomial SBP. ⋯ Resistance to initial antibiotic treatment was associated with increased mortality. With resistance to cephalosporins being frequent, piperacillin-tazobactam or carbapenems might be preferred as treatment of SBP.
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IL-1β is a primary mediator of systemic inflammatory response syndrome (SIRS) and it may lead to shock septic. Our aim was to analyse whether IL-1B rs16944 polymorphism is associated with the onset of septic shock and death after major surgery. ⋯ IL-1B rs16944 AA genotype seems to be related to the onset of septic shock and death in patients who underwent major surgery.
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Eur. J. Clin. Invest. · Jan 2017
Hepatic chemerin mRNA expression is reduced in human nonalcoholic steatohepatitis.
Chemerin is associated with insulin resistance and is expressed in the liver. Nonalcoholic fatty liver disease (NAFLD) is related to impaired insulin sensitivity, but studies evaluating hepatic and serum chemerin in NAFLD resulted in discordant data. ⋯ Chemerin mRNA is reduced in the liver of NASH patients, and liver X receptor seems to have a role herein.