• Rafael Y Brzezinski, Eyal Fisher, Michal Ehrenwald, Gabi Shefer, Naftali Stern, Itzhak Shapira, David Zeltser, Shlomo Berliner, Shani Shenhar-Tsarfaty, Assi Milwidsky, and Ori Rogowski.
• Department of Internal Medicine "C", "D" and "E", Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
• Eur. J. Clin. Invest. 2018 Jun 1; 48 (6): e12930.

BackgroundThe exercise ECG stress test (EST) is still the first step of work-up in intermediate risk patients in many clinical scenarios. High-sensitive cardiac troponin T (hs-cTnT) elevation is related to future cardiovascular events in the general population and in patients with ischaemic heart disease. The relation between these 2 tests is not well described.Materials And MethodsA total of 2780 participants from the Tel-Aviv Medical Center Inflammation Survey cohort (mean age 49 years, 79% men) were analysed. Multiple physiologic and metabolic parameters including hs-cTnT were collected. All participants completed an EST manually reviewed by a cardiologist.ResultsA positive EST was documented in 224 subjects (8%). The majority (91%) of participants with hs-cTnT levels of 5-14 ng/L had a negative EST as well as 89.3% of subjects with levels >14 ng/L. The proportion of subjects with a positive EST and detectable hs-cTnT levels (>5 ng/L) was not significantly greater compared to those with a negative EST (53.1% vs 46.2%, respectively, P = .09).ConclusionAmong subjects referred for EST as part of an annual health survey, we found no significant association between EST results to hs-cTnT detection.© 2018 Stichting European Society for Clinical Investigation Journal Foundation.

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