• N Malek and M R Baker.
• Department of Neurology, Ipswich Hospital NHS Trust, Ipswich, UK.
• Postgrad Med J. 2017 Jun 1; 93 (1100): 326-332.

BackgroundPhysicians can come across patients who are exposed to certain prescription drugs or toxins that can result in adverse effects and complications which have high rates of morbidity and mortality.ObjectiveTo summarise the key clinical features and management of the common movement disorder toxidromes relevant to physicians (with an interest in neurology).MethodsWe searched PUBMED from 1946 to 2016 for papers relating to movement toxidromes and their treatment. The findings from those studies were then summarised and are presented here.ResultsThe key features of 6 of the common movement disorder toxidromes and their treatment are tabulated and highlighted. The management of toxidromes with the highest mortality like neuroleptic malignant syndrome and serotonin syndrome are discussed in detail.ConclusionThere are several toxidromes that have the potential to become a serious life-threatening emergency if there is a delay in recognition of key clinical features and instituting the appropriate treatment at the earliest is crucial.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

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