• Betina Chandolia, Jai Parkash Rajliwal, Manas Bajpai, and Manika Arora.
• Department of Oral Pathology, NIMS Dental College, Shobha Nagar, Jaipur, India.
• J Coll Physicians Surg Pak. 2017 Aug 1; 27 (8): 475-478.

ObjectiveTo assess the prognostic potential for N-cadherin in oral squamous cell carcinoma and oral epithelial dysplasia.Study DesignAcross-sectional study, analytical study.Place And Duration Of StudyMaharishi Markandeshwar College of Dental Science Research (MMCDSR), Ambala, India, from 2011 to 2014.MethodologyImmunohistochemistry was used to observe the N-cadherin expression in 100 cases having epithelium with normal oral mucosa, oral epithelial dysplastic lesions and oral squamous cell carcinoma (OSCC). For statistical significance, SPSS 13.0 was used to calculate the data by Mann-Whitney and Kruskal-Wallis tests.ResultsIn OSCC, N-cadherin expression was more evident than in oral epithelial dysplasia followed by the normal oral epithelium that did not show any dysplastic changes (p=0.001). Conversely, N-cadherin expression was not significant among the histological grade of OSCC.ConclusionN-cadherin can be used as a potential biomarker for early diagnosis of OSCC. However, the N-cadherin expression did not show any correlation with the histological grade of OSCC.

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