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- Kiran Vasudeva, Yoram Vodovotz, Nabil Azhar, Derek Barclay, Jelena M Janjic, and John A Pollock.
- Department of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA; Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA 15282, USA. Electronic address: vasudevak@duq.edu.
- J. Neuroimmunol. 2015 Jun 15;283:43-9.
AbstractInflammation is associated with peripheral neuropathy, however the interplay among cytokines, chemokines, and neurons is still unclear. We hypothesized that this neuroinflammatory interaction can be defined by computational modeling based on the dynamics of protein expression in the sciatic nerve of rats subjected to chronic constriction injury. Using Dynamic Bayesian Network inference, we identified interleukin (IL)-18 as a central node associated with neuropathic pain in this animal model. Immunofluorescence supported a role for inflammasome activation and induction of IL-18 at the site of injury. Combined in vivo and in silico approaches may thus highlight novel targets in peripheral neuropathy.Copyright © 2015 Elsevier B.V. All rights reserved.
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