• African health sciences · Jun 2016

    Comparative Study

    Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease.

    • Jia-Jun Ye, Tian-Biao Zhou, Yun-Fang Zhang, Qi Wang, Yan-Yan Su, Jia-Min Tang, and Hong-Yan Li.
    • Department of Nephrology, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China.
    • Afr Health Sci. 2016 Jun 1; 16 (2): 462-7.

    ObjectiveThis study was performed to detect the expression of vitamin D receptor (VDR) and cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1) in 24 end stage renal disease (ESRD) patients and 24 healthy controls.MethodIn this study, 24 ESRD patients and 24 healthy controls were included.ResultsIn our study, the levels of VDR in patients with ESRD were reduced when compared with those from healthy controls (5.20±0.32 vs 8.59±1.03; P<0.01). However, the levels of CYP24A1 in ESRD patients were increased than those from healthy controls (50.18±21 vs 7.78±1.31; P<0.01). Correlation analysis showed that VDR levels were negatively correlated with CYP24A1 (r=-0.723; P<0.01).ConclusionVDR levels were reduced and CYP24A1 levels were increased in patients with ESRD, and VDR levels were negatively correlated with CYP24A1.

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