• African health sciences · Jun 2017

    Expression of miR-126 and its potential function in coronary artery disease.

    • Xiaoyan Wang, Yajun Lian, Xin Wen, Jing Guo, Zhiping Wang, Sheng Jiang, and Yaodong Hu.
    • Department of Ultrasound, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China.
    • Afr Health Sci. 2017 Jun 1; 17 (2): 474-480.

    ObjectiveThis study aimed to explore the role of miR-126 in coronary artery disease (CAD) patients and the potential gene targets of miR-126 in atherosclerosis.MethodologyA total of 60 CAD patients and 25 healthy control subjects were recruited in this study. Among the 60 CAD patients, 18 cases were diagnosed of stable angina pectoris (SAP), 20 were diagnosed of unstable angina pectoris (UAP) and 22 were diagnosed of acute myocardial infarction (AMI). Plasma miR-126 levels from both groups of participants were analyzed by real-time quantitative PCR. ELISA was used to measure plasma level of placenta growth factor (PLGF).ResultsThe results showed that the miR-126 expression was significantly down-regulated in the circulation of CAD patients compared with control subjects (P<0.01). Plasma PLGF level was significantly upregulated in patients with unstable angina pectoris and acute myocardial infarction (AMI) compared with controls (both P<0.01) the miR-126 expression in AMI was significantly associated with PLGF.ConclusionmiR-126 may serve as a novel biomarker for CAD.

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