• African health sciences · Sep 2018

    Meta Analysis Comparative Study

    A meta-analysis of phosphate binders lanthanum carbonate versus sevelamer hydrochloride in patients with end-stage renal disease undergoing hemodialysis.

    • Tianbiao Zhou, Hongyan Li, Weiji Xie, and Zhijun Lin.
    • Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, 515041, Shantou, China.
    • Afr Health Sci. 2018 Sep 1; 18 (3): 689-696.

    Background And ObjectivesThe purpose of this study was to compare the effects of phosphate binders lanthanum carbonate (LC) versus sevelamer hydrochloride (SH) in end-stage renal disease (ESRD) patients undergoing hemodialysis.MethodsStudies including randomized controlled trials (RCTs) comparing phosphate binders lanthanum carbonate versus sevelamer hydrochloride, in ESRD patients undergoing hemodialysis, were identified using a pre-defined search strategy. Phosphate, calcium, calcium-phosphorus product, intact parathyroid hormone, alkaline phosphatase, total cholesterol, and triglyceride were extracted and compared by RevMan 5.1 (The Cochrane Collaboration, Oxford, UK).ResultsSix studies were identified. Meta-analysis showed that SH treatment reduced levels of phosphate, intact parathyroid hormone, and total serum alkaline phosphatase (ALP) when compared with LC treatment. Furthermore, patients on SH treatment tended to have reduced calcium levels, calcium-phosphorus product, total cholesterol, and triglyceride when compared to patients treated with LC, but there was no statistical difference.ConclusionSH treatment of patients with ESRD is more effective compared to LC treatment. However, more well-designed random control trails are required for confirmation.

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