• Haiying Chen, Yuxiang Li, Peng Zhang, and Yang Wang.
• Department of Infectious Diseases, The First Hospital, Jilin University, Changchun, Jilin, China.
• Medicine (Baltimore). 2020 Apr 1; 99 (14): e19734.

RationaleBleeding in the anterior pituitary lobe leading to tissue necrosis occurs in the acute stage of severe clinical forms of hemorrhagic fever with renal syndrome (HFRS), while atrophy of the anterior pituitary lobe with diminution of the gland function occurs after the recovery stage. The relationship between Hantaan virus infection and empty Sella syndrome (ESS) has rarely been reported.Patient ConcernsThis patient was a 54-year-old previously healthy Chinese male. He presented with fever, headache, and backache with dizziness and oliguria. Physical examination was notable for hypotension and the signs of conjunctival suffusion. His platelets decreased, and his urine protein was positive. Hantaan virus IgM and virus RNA were positive.DiagnosisHe was diagnosed as having HFRS. In his diuretic phase, his 24-hour urine volume was maintained at 10,000 mL, and his blood pressure was higher for a week. Then, he was diagnosed as having ESS after a series of examinations.InterventionsHormone replacement therapy was given to this patient after the diagnosis "ESS" was made.OutcomesThe patient's symptoms improved, and he was discharged from the hospital soon after hormone replacement therapy.LessonsPituitary function examination and brain magnetic resonance imaging (MRI) need to be considered to scan for ESS and panhypopituitarism in the patients with HFRS accompanied by diabetes insipidus.

7 keywords...

hide…