• Emerg Med Australas · Jun 2022

    Venous blood for the analysis of acid-base status in a model of septic shock.

    • Matthew J Maiden, Jonathan D Fraser, and Mark E Finnis.
    • Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
    • Emerg Med Australas. 2022 Jun 1; 34 (3): 456-458.

    ObjectiveTo determine the relationship between arterial and venous acid-base status in a model of septic shock.MethodsPaired samples (n = 435) of arterial and femoral venous blood from 57 sheep (47 septic, 10 non-septic) managed with protocol-guided ventilation, sedation, parenteral fluids and inotropic support.ResultsThe arterial-venous difference in acid-base parameters was similar with and without sepsis. There was a consistent arterio-venous relationship for metabolic (pH, lactate, bicarbonate, base excess), but not respiratory parameters (partial pressures of oxygen, carbon dioxide, and haemoglobin-oxygen saturation), independent of sepsis.ConclusionsVenous blood provides a reliable measure of metabolic but not respiratory disturbance.© 2022 The Authors. Emergency Medicine Australasia published by John Wiley & Sons Australia, Ltd on behalf of Australasian College for Emergency Medicine.

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