• Curr Med Res Opin · Jun 2022

    Meta Analysis

    Risk of Parkinson's disease in glaucoma patients: a systematic review and meta-analysis.

    • Bill Zhao, Ronald Cheung, and Monali S Malvankar-Mehta.
    • Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada.
    • Curr Med Res Opin. 2022 Jun 1; 38 (6): 955-962.

    ObjectiveTo conduct a systematic review and meta-analysis to evaluate the relationship between glaucoma and the risk of Parkinson's disease.MethodsA systematic search of databases including MEDLINE, EMBASE, and CINAHL were conducted. Grey literature search, including Dissertations and Theses databases and conference abstracts, was performed. Duplicates were removed, and two independent reviewers conducted the screening. We included any primary observational studies that examined the relationship between glaucoma and Parkinson's disease. Study characteristics along with relevant outcome measurements such as hazard ratio (HR), odds ratio (OR), and prevalence were extracted. Meta-analysis using STATA 15.0 was performed, and the presence of heterogeneity was determined using I2 statistics, Z-test, and p-value.ResultsA total of 746 citations were found through the databases and grey literature searches. After screening, five studies met the inclusion criteria, and three studies were included in the meta-analysis. There was a non-significant hazard of developing Parkinson's disease (Hazard Ratio = 1.13, 95% CI: [0.99, 1.29]) in patients with glaucoma compared to controls.DiscussionThe hazard of developing Parkinson's disease was non-significantly different for those with glaucoma compared to controls; however, there were not enough studies available to draw definitive conclusions.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.