• Hülya Kaşıkara, Ayça T Dumanlı Özcan, Cemile K Biçer, Almila Şenat, Abdüssamet Yalçın, Cemile Altın, Mustafa AksoyŞemsiŞFrom the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the De, and Abdülkadir But.
• From the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
• Saudi Med J. 2022 Mar 1; 43 (3): 227-235.

ObjectivesTo assess the impact of low-flow, mid-flow, and high-flow sevoflurane anesthesia on the oxidative state by measuring thiol/disulfide levels in patients undergoing surgery.MethodsThe study included 99 patients randomly assigned to 3 groups. In the low-flow anesthesia group, the fresh gas flow was diminished to 1 L.min-1 for anesthesia maintenance after 6 L.min-1 was administered for the first 10 minutes. In the mid-flow anesthesia group, fresh gas flow was applied as 2 L.min-1. In the high-flow anesthesia group, the fresh gas flow was administered as 4 L.min-1 throughout the operation. Blood samples were obtained before induction, at the 60th minute after induction, and at 2 hours postoperatively. Native thiol, total thiol, disulfide analyzed and disulfide/native thiol percentage, disulfide/total thiol percentage, and native thiol/total thiol percentage were calculated.ResultsDisulfide values in mid-flow and low-flow anesthesia were significantly lower at the 60th minute after induction compared to the high-flow anesthesia group. In the group evaluations, intraoperative native thiol levels in the high-flow group were found to be substantialy lower than preoperative values.ConclusionIt was sighted that low-flow anesthesia with sevoflurane prohibited oxidative damage. It was concluded that low flow anesthesia can be utilized safely in this respect.Copyright: © Saudi Medical Journal.

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