• Emrah Keskin, Çağhan Tönge, Mustafa Kaya, and Emre Işık.
• From the Department of Neurosurgery (Keskin), Faculty of Medicine, Zonguldak Bülent Ecevit University, Zonguldak; from the Department of Neurosurgery (Tönge), University of Health Sciences, Gulhane School of Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara; from the Department of Neurosurgery (Kaya), Sakarya University Education and Research Hospital, Sakarya; and from the Department of Pathology (Işık), Tunceli State Hospital, Tunceli, Turkey.
• Saudi Med J. 2022 Apr 1; 43 (4): 370377370-377.

ObjectivesTo evaluate the effect of berberine (BBR) in preventing the development of epidural fibrosis (EF) after lumbar surgery in rats.MethodsThis experimental study was carried out at the animal laboratory of Zonguldak Bülent Ecevit University, Zonguldak, Trurkey, between April 2020 and June 2020. A total of 32 Wistar albino female rats underwent laminectomy and were divided into 4 equal groups. Group 1 did not receive any treatment (control group). In group 2, absorbable gelatin sponge was placed at the surgical site. Groups 3 was administered BBR 10 mg/kg and group 4 was administered BBR 60 mg/kg per oral per day for one week after laminectomy. All rats were sacrificed 6 weeks after the operation. Concentration of hydroxyproline (HP) in tissues and histopathological evaluations were carried out to evaluate the level of fibrosis.ResultsEpidural fibrosis results in group 4 were significantly lower than those in groups 1 and 2 (p≤0.001). However, there was no significant difference between the mean EF degree between group 2 and group 3. Arachnoidal invasion in both group 3 and group 4 were significantly lower compared to group 1 (p<0.05). In terms of HP results, the difference between group 4 and group 1 was statistically significant (p<0.001).ConclusionThis study provides preliminary evidence of the potential use of BBR for preventing the development of EF.Copyright: © Saudi Medical Journal.

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