• Saudi Med J · Apr 2022

    Disease-specific quality of life in patients with diabetic neuropathy.

    • Mushabab Alghamdi, Lukman F Owolabi, Bappa Adamu, Magaji G Taura, Abubakar Jibo, Mohammed Almansour, Saeed N Alaklabi, Mohammed A Alghamdi, Isa A Imam, Reda Abdelrazak, Ahmad Rafaat, and Muktar H Aliyu.
    • From the Departmentof Internal Medicine (Alghamdi M, Owolabi, Adamu, Taura, Jibo, Alaklabi, Alghamdi MA, Imam, Abdelrazak), University of Bisha Medical College; from the Departmentof Internal Medicine(Rafaat), King Abdullah Hospital, Bisha; from the Departmentof Internal Medicine (Almansour), King Fahad Medical City, Riyadh; from the Department of Health Policy (Aliyu), Vanderbilt University Medical Center, Nashville, United States of America.
    • Saudi Med J. 2022 Apr 1; 43 (4): 408417408-417.

    ObjectivesTo compare health-related quality of life (HRQoL) among patients with diabetes mellitus (DM) and diabetic neuropathy (DN) (D+N) with patients with DM without DN (D-DN) and healthy participants. To evaluate factors associated with poor HRQoL in patients with DN.MethodsThis study included 306 participants residing in Bisha, Saudi Arabia. Patients with DM were screened for DN using the Michigan Neuropathy Screening Instrument. Neuropathy severity, disability and HRQoL were determined using the Neuropathy Severity Scale (NSS), the Neuropathy Disability Score (NDS), and the Norfolk Quality of Life-Diabetic Neuropathy (QOL-DN) tool, respectively. Nerve conduction studies (NCSs) were also performed.ResultsThe D+DN group had poorer overall and domain HRQoL scores compared to the D-DN group (p<0.001). There was a strong correlation between overall HRQoL score and both NDS and NSS scores in the D+DN group (ρ= -0.71 and p<0.0001; ρ= -0.81 and p<0.0001, respectively). There was also a significant difference in all mean HRQoL domain scores between D+DN participants with normal and abnormal NCS. Physical inactivity (p=0.043), duration of DM (p<0.0001), abnormal NCS, NSS (p<0.0001), and NDS (p<0.0001) predicted HRQoL in the D+DN group.ConclusionD+DN participants had a worse HRQoL compared with D-DN and healthy counterparts. NDS, NNS, physical inactivity, abnormal NCS, and duration of DM independently predicted poor HRQoL in D+DN participants.Copyright: © Saudi Medical Journal.

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