• Chao-Wen Lu, Wang-Da Liu, Hsao-Hsun Hsu, Un-In Wu, Yung-Ming Jeng, Yee-Chun Chen, and Jin-Shing Chen.
• Division of Thoracic Surgery, Department of Surgery, National Taiwan University Hospital, and National Taiwan University College of Medicine, Taiwan.
• J Formos Med Assoc. 2022 Nov 1; 121 (11): 2237-2247.

BackgroundThe surgical outcome for primary pulmonary cryptococcosis remains unclear. In this study, we investigated the clinical characteristics, treatment, and outcomes of video-assisted thoracoscopic surgery (VATS) for primary pulmonary cryptococcosis.MethodsWe retrospectively reviewed the medical records of 49 patients with confirmed pulmonary cryptococcosis who underwent VATS for pulmonary nodules at the National Taiwan University Hospital between May 2013 and March 2019. Serum cryptococcal antigen (CryAg)-positive and CryAg-negative patients were compared.ResultsThe diagnosis of pulmonary cryptococcosis was confirmed using histopathology or tissue swab culture. The mean age of the patients was 56.0 ± 12.2 years, and 27 patients (55.1%) were male. Most patients were asymptomatic (67.3%) and admitted following the detection of pulmonary lesions on a computed tomography scan of the chest. A greater proportion of patients in the CryAg-positive group (62.5%) underwent lobectomy compared with those in the CryAg-negative group (7.3%, P < 0.001). Three patients (6.1%) had neurological symptoms (headache or dizziness) and all were serum CryAg-positive. One patient with Cryptococcus gattii developed fluctuating serum CryAg titers after a 12-month antifungal treatment. No relapse occurred in the remaining 48 patients, irrespective of postoperative antifungal treatment.ConclusionIn patients with primary pulmonary cryptococcosis, serum CryAg detection rate is low, and VATS was an effective and safe diagnostic and therapeutic tool.Copyright © 2022 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.

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