• World Neurosurg · May 2022

    Hydrocephalus Study Design: Testing New Hypotheses in Clinical Studies and Bench-to-Bedside Research.

    • Marianne Juhler, Torben Skovbo Hansen, Hans V G Novrup, Nanna MacAulay, and Tina Nørgaard Munch.
    • Department of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address: marianne.juhler@gmail.com.
    • World Neurosurg. 2022 May 1; 161: 424-431.

    AbstractIn this article, we aimed to describe some of the currently most challenging problems in neurosurgical management of hydrocephalus and how these can be reasons for inspiration for and development of research. We chose 4 areas of focus: 2 dedicated to improvement of current treatments (shunt implant surgery and endoscopic hydrocephalus surgery) and 2 dedicated to emerging future treatment principles (molecular mechanisms of cerebrospinal fluid secretion and hydrocephalus genetics).Copyright © 2022 Elsevier Inc. All rights reserved.

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