• J F Morici, G Cicuttin, A Silva, F T Gallo, M Miranda, M Belluscio, C Zold, P Bekinschtein, and N V Weisstaub.
• Instituto de Neurociencia Cognitiva y Traslacional, Concejo Nacional de Investigaciones Científicas y tecnológicas (CONICET), Universidad Favaloro, Instituto de Neurología Cognitiva (INECO), Pacheco de Melo 1860, C1126AAB Buenos Aires, Argentina.
• Neuroscience. 2022 Aug 10; 497: 196-205.

AbstractPrevious experiences can drive adaptive behavior based on different characteristics, including contextual ones. Indeed, contextual information can be used as a criterion to guide the recall of the most relevant memory trace and the inhibition of others. The medial Prefontal Cortex (mPFC) has been proposed as an area that plays a pivotal role in regulating the retrieval of memory traces in downstream regions. Also, we have shown that mPFC Serotonin 2a Receptors (5-HT2aR) modulates the retrieval of a contextually guided recognition memory task and modulates the retrieval and reconsolidation of memories in the Perirhinal Cortex (PRH). However, how the mPFC output mediated by the 5-HT2aR activity is modulating memory retrieval in the PRH is a question that remains unclear. To tackle this question, we analyzed neuronal activity in the PRH and mPFC, by measuring expression of the immediate early gene c-Fos. We combined behavioral, pharmacological and immunohistochemical techniques to examine how mPFC 5-HT2aR controls mPFC and the PRH activity. We found that blockade of mPFC 5-HT2aR increase the level of c-Fos expression in the PHR and that this increase correlates with animals' performance in the task. We also found an increase in c-Fos expression in the mPFC after mPFC 5-HT2aR blockade that does not correlate with the animals' behavioral response. However, these changes showed a significant correlation with those observed in the PRH. These results suggest that mPFC 5-HT2aR signaling may modulate the behavioral response during memory recall by controlling the neuronal activation in the PRH.Copyright © 2022 IBRO. Published by Elsevier Ltd. All rights reserved.

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