• Medicine · May 2022

    Meta Analysis

    Clinical impact of pretreatment albumin-globulin ratio in patients with colorectal cancer: A meta-analysis.

    • Jian-Ying Ma, Gang Liu, Liang-Zhi Pan, Min Hu, and Zhong-Zhong Zhu.
    • Department of Breast Surgery, Thyroid Surgery, Huangshi Central Hospital of Edong Healthcare Group, Hubei Polytechnic University, No.141, Tianjin Road, Huangshi, Hubei, China.
    • Medicine (Baltimore). 2022 May 20; 101 (20): e29190e29190.

    BackgroundAccumulating evidence have revealed that pretreatment albumin to globulin ratio (AGR) may be a predictor of prognosis among patients with colorectal cancer (CRC). However, these findings are inconsistent. The aim of the present study was to investigate the prognostic value of pretreatment AGR in CRC.MethodsA systematic meta-analysis was conducted by searching MEDLINE, EMBASE, and Cochrane Library databases.ResultsA total of 9 studies with 7939 patients were finally included. Low pretreatment AGR was associated with worse overall survival (pooled hazard ratio [HR]: 2.07, 95% CI: 1.60-2.67, P < .001) and disease-free survival/progress-free survival (pooled hazard ratio [HR]: 2.10, 95% confidence interval [CI]: 1.34-3.31, P = .001). Subgroup analyses revealed that the pooled correlation did not alter these results. Moreover, low pretreatment AGR were associated with elderly patients, tumor diameter (≥50 mm), tumor node metastasis stage (III-IV), depth of tumor (T3-4), and CA19-9 (>37 U/mL).ConclusionThe present meta-analysis suggests that low pretreatment AGR was associated with advanced clinicopathological features and worse prognosis, suggesting AGR is a useful prognostic biomarker for CRC patients.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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