• Tohoku J. Exp. Med. · Jul 2022

    Epifriedelinol Ameliorates DMBA-induced Breast Cancer in Albino Rats by Regulating the PI3K/AKT Pathway.

    • Jing Zhang, Yang He, Ying Zhou, Liping Hong, Zhansheng Jiang, Ying Zhao, and Zhanyu Pan.
    • Department of Integrative Oncology, Tian Jin Cancer Hospital Airport Hospital.
    • Tohoku J. Exp. Med. 2022 Jul 13; 257 (4): 283-289.

    AbstractWe evaluated the protective effect of epifriedelinol against breast cancer and postulated an underlying mechanism. Breast cancer was induced by a single dose of 50 mg/kg 7,12-Dimethylbenanthracene (DMBA), and rats were treated with 100 or 200 mg/kg (i.p.) epifriedelinol for 4 weeks. We then evaluated the effect of epifriedelinol on tumor growth, oxidative stress and serum inflammatory cytokine levels in DMBA-induced breast cancer. Protein and mRNA levels were determined using western blotting and quantitative reverse transcription polymerase chain reaction, respectively. The tumor volume and weight were significantly (p < 0.01) decreased in the epifriedelinol-treated group compared to the negative control group. Epifriedelinol decreased the altered levels of oxidative stress and serum inflammatory cytokines in rats with DMBA-induced breast cancer. Protein levels of PI3K, AKT and mTOR and mRNA levels of PI3K, AKT, Map3k1, Erbb2 and Pdk1 were decreased in the mammary tissue of epifriedelinol-treated rats with DMBA-induced breast cancer. Apoptosis was significantly induced in the epifriedelinol-treated group compared to the negative control group. In conclusion, epifriedelinol ameliorates DMBA-induced breast cancer by regulating the PI3K/AKT pathway.

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