• Medicine · May 2022

    IFNL4, ACE1, PKR, IFNG, MBL2 genetic polymorphisms and severe COVID-19: A protocol for systematic review and meta-analysis.

    • Hengjia Tu and Junrong Bao.
    • Guangzhou Medical University, Xinzao, Panyu District, Guangzhou City, Guangdong Province, People's Republic of China.
    • Medicine (Baltimore). 2022 May 27; 101 (21): e29405e29405.

    BackgroundCorona virus disease 2019 (COVID-19) is caused by SARS-CoV-2, the pathogenic process of SARS-Cov-2 is related to the angiotensin-2 converting enzyme (ACE-2) on host cells. The genetic polymorphisms among different populations may influence the progression of COVID-19. However, the effects of IFNL4, ACE1, PKR, IFNG, and MBL2 in severe COVID-19 have not been systematically assessed.MethodsWe will include all relevant English and Chinese studies by searching the following electronic databases: PubMed, MEDLINE, Embase, Web of Science, Scopus, the Cochrane Library, and Google Scholar before March 31, 2022. Two researchers will independently screen and extract the literature. The methodological quality of the included studies will be evaluated by the Cochrane Handbook for Systematic Reviews of Interventions.ResultThis systematic review and meta-analysis will summarize the association of IFNL4, ACE1, PKR, IFNG, MBL2 genetic polymorphisms, and severe COVID-19. The results will be submitted to a peer-reviewed journal once completed.ConclusionThe conclusion of our study will provide evidence for the early prevention of severe COVID-19.Prospero Registration NumberCRD42022301735.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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