• Pak J Med Sci · Mar 2022

    Effect of glucocorticoids combined with disease modifying anti-rheumatic drugs on the improvement of symptoms in patients with rheumatoid arthritis.

    • Lulu Si, Yunyan Jin, Dongni Zhao, Lixia Yu, and Huankun Cao.
    • Lulu Si, Department of Rheumatology and Immunology, Yiwu Central Hospital, 519 Nanmen Street, Yiwu, Zhejiang Province 322000, P.R. China.
    • Pak J Med Sci. 2022 Mar 1; 38 (4Part-II): 976-980.

    ObjectivesTo explore the effect of glucocorticoids combined with disease modifying anti-rheumatic drugs in the treatment of symptoms in patients with rheumatoid arthritis.MethodsMedical records of patients with rheumatoid arthritis treated in the Rheumatology and Immunology Department of Yiwu Central Hospital from March 2020 to March 2021 were selected. A total of 38 patients were treated with disease modifying anti-rheumatic drugs Group-I and 44 patients were treated with disease modifying anti-rheumatic drugs and glucocorticoids Group-II. The symptom improvement of the two groups were compared and analyzed Serological indexes and adverse reactions.ResultsSwollen joint counts (SJC), tender joint counts (TJC), rheumatoid arthritis disease activity evaluation form (DAS28) score, erythrocyte sedimentation rate, levels of ESR, C-reaction protein (CRP) and rheumatoid factor (RF) of Group-II patients were lower than those in Group-I (P<0.05). The adverse reaction rate in Group-II patients was 12.20%, which was similar to that of Group-I patients. There was no significant difference in 9.76% of the patients (P>0.05).ConclusionThe combination of glucocorticoids and disease modifying anti-rheumatic drugs in the treatment of patients with rheumatoid arthritis is safe can further improve their symptoms and serological indexes, and will not lead to increased adverse reactions.Copyright: © Pakistan Journal of Medical Sciences.

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