• Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, and Masao Akagi.
• Department of Orthopedic Surgery, Kindai University Hospital, Osaka-Sayama City, Japan.
• Medicine (Baltimore). 2022 Jun 3; 101 (22): e29471e29471.

IntroductionA giant cell tumor of soft tissue (GCST) is a benign soft tissue tumor that often occurs subcutaneously in the extremities. Rare cases of malignant GCST have been reported, but its pathogenesis remains unclear.Patients ConcernsWe report a case of a 68-year-old man who noticed a painless mass on his second toe one and a half years ago. He visited the Department of Dermatology at our hospital. Magnetic resonance imaging revealed a soft tissue tumor, surrounding the distal aspect of the second toe.DiagnosisA biopsy of the tumor was performed by a dermatologist, and it revealed a malignant giant cell tumor of the toe.InterventionsHe was referred to our department and underwent lay amputation for wide-margin resection.OutcomesNo recurrence or metastasis was observed 5 years after treatment.Conclusion: Malignant GCST should be treated with wide-margin resection immediately after its diagnosis.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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