• Yi-Jie Zhang, Yan Zhu, Li Zhu, Cheng-Qiu Lu, Chao Chen, and Lin Yuan.
• From the Department of Neonatology (Zhang, Zhu Y, Zhu L, Chen, Yuan), Children's Hospital of Fudan University, from the Division of Neonatology (Lu), Gynecology and Obstetrics Hospital of Fudan University; and from the Key Laboratory of Neonatal Diseases (Chen), National Health Commission, Shanghai, China.
• Saudi Med J. 2022 Jun 1; 43 (6): 599-609.

ObjectivesTo investigate the prevalence of preterm birth (PTB) and the risk factors for different gestational age subgroups of preterm birth in China.MethodsWe carried out a descriptive cross-sectional study encompassing all singleton live births (24+0 to 41+6 weeks) with completed data in 23 provinces in China from 2010 to 2017 during investigation period. We compared both the preterm group (24+0 to 36+6 weeks) and preterm subgroups (<32 weeks, 32+0 to 33+6 weeks, and 34+0 t0 36+6 weeks) with the term group (37+0 to 41+6 weeks). We collected information on maternal and fetal characteristics from medical records. Logistic regression was use.ResultsThe prevalence of PTB was 7.4% (15,833/215,254) in singleton births. After adjusting for maternal age, parity, and potential risk factors in univariate analysis, the high-risk factors for PTB at <32 weeks were placental abruption (aOR=41.52; 95% CI, 25.89-66.58), placenta previa (aOR=40.04; 95% CI, 32.00-50.09), chorioamnionitis (aOR=11.06; 95% CI, 8.738-14.02), and hypertension disorders in pregnancy (HDP) (aOR=3.564; 95% CI, 2.930-4.335). Intrahepatic cholestasis of pregnancy (ICP) was significantly associated with PTB at 34-36 weeks (aOR=5.763; 95% CI, 5.049-6.577), particularly with spontaneous PTB (aOR=10.04; 95% CI, 8.79-11.47). Gestational diabetes mellitus (GDM) was significantly associated with PTB at 34-36 weeks only (aOR=1.156; 95% CI, 1.054-1.267).ConclusionPlacental abruption, placenta previa, chorioamnionitis, and HDP were more predictive of early PTB; GDM and ICP were more predictive of late PTB.Copyright: © Saudi Medical Journal.

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