• Ugur Topal, Serkan Guler, Zafer Teke, Erdal Karakose, Idris Kurtulus, and Hasan Bektas.
• Department of Surgical Oncology, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.
• J Coll Physicians Surg Pak. 2022 Jun 1; 32 (6): 751-757.

ObjectiveTo investigate the value of preoperative haemoglobin, albumin, lymphocyte, and platelet (HALP) score in predicting tumour budding in colorectal carcinoma.Study DesignObservational study.Place And Duration Of StudyUniversity of Health Sciences, Başakşehir Çam and Sakura City Hospital İstanbul/Turkey, between May 2020 and May 2021.MethodologyThe colorectal cancer patients who underwent surgery were divided into two groups according to the presence or absence of tumour budding. A total of 110 patients were included in the study, and there were 31 patients in group 1 and 79 patients in group 2. The predictive value of the HALP score in predicting tumour budding at the determined cut-off point was evaluated.ResultsThe mean HALP score was similar in both groups (p=0.459). The rate of lymphovascular invasion was higher in group 2 (p=0.002), and T3 and T4 tumours were more common in group 2 (p<0.001). The number of metastatic lymph nodes was higher in group 2 (p=0.049). When the patients in group 2 were divided into subgroups according to the degree of tumour budding, the HALP score differed between intermediate and high budding groups (p=0.032). A HALP value of >31.6 predicted the presence of tumour budding with a sensitivity of 70.89% and a specificity of 48.39%.ConclusionThe presence of tumour budding is associated with aggressive phenotypic features in colorectal carcinoma. The preoperative prediction of tumour budding can serve as a guide in the development of individualised therapy plans. The HALP score was associated with the presence of intermediate or high degree of tumour budding.Key WordsColorectal cancer, Tumor, Pathology, Hemoglobin, Albumin.

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