• Cagdas Senel, Ahmet Asfuroglu, Ibrahim Can Aykanat, Melih Balci, Yilmaz Aslan, and Altug Tuncel.
• Department of Urology, Balikesir University School of Medicine, Balikesir, Turkey.
• J Coll Physicians Surg Pak. 2022 Jun 1; 32 (6): 768-772.

ObjectiveTo assess the effect of the urinary pH value on the efficacy of a postoperative single instillation of mitomycin-C.Study DesignA descriptive study.Place And Duration Of StudyDepartment of Urology, Ankara Numune Training and Research Hospital, Ankara, Turkey from 2011 to 2016.MethodologyPatients newly diagnosed with low-risk non-muscle invasive bladder cancer and given a postoperative single instillation of mitomycin-C were retrospectively reviewed. The demographic data and pre-instillation urinary pH values of the patients were recorded. All patients included in the study (n=117) were followed up for five years. The primary outcome was the time to the first recurrence. The patients were divided into two groups: Group 1 consisted of 87 patients with no recurrence and Group 2 comprised 30 patients that had recurrence during the follow-up.ResultsThe mean pre-instillation urinary pH value was significantly lower in Group 2 than in Group 1 (5.89 vs. 5.37, p <0.001). The receiver operating characteristic analysis revealed that the cut-off value of urinary pH in predicting recurrence was 5.25. The patients with a urinary pH value of 5.25 or greater had significantly higher recurrence-free survival rates.ConclusionsThe patients with higher urinary pH before a single instillation of mitomycin-C had better recurrence-free survival.Key WordsBladder cancer, Mitomycin-C, Single instillation, Urinary pH.

18 keywords...

hide…