• Rev Med Interne · Aug 2022

    [Epstein-Barr Virus and systemic lupus: Which connections?]

    • A Enfrein and M Hamidou.
    • Service de médecine interne, PHU3, CHU de Nantes, 1, Places Alexis-Ricordeau, 44093 Nantes, France. Electronic address: antoine.enfrein@chu-nantes.fr.
    • Rev Med Interne. 2022 Aug 1; 43 (8): 487-493.

    AbstractSystemic lupus erythematosus (SLE) is a complex multifactorial autoimmune disease depending on both intrinsic and environmental factors. Among the latter, the Epstein-Barr Virus (EBV) has long been suggested as one of the responsible factors for the onset and activity of lupus disease. It is a herpes virus with a very specific tropism for B lymphocytes and therefore closely linked to the immune system. EBV infection almost always precedes the onset of lupus disease and in vitro data and animal models suggest that anti-EBV response may favor the development of autoantibodies and lupus disease in some subjects. Also, there are abnormalities in humoral and cellular responses to EBV and lupus patients have impaired control of EBV, with higher blood viral loads. Interstingly, this virus seems to be able to promote disease activity, by promoting the survival of autoreactive B lymphocytes and the production of interferon-α, which are two pivotal mechanisms in the pathophysiology of lupus disease.Copyright © 2022 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

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