• Farzin Sadeghi, Abazar Pournajaf, Mehrdad Halaji, Mohammad Chehrazi, Fatemeh Hejazi Amiri, Saghar Saber Amoli, Ali Hasanzadeh, Mostafa Javanian, Masoumeh Bayani, Mahmoud Sadeghi Haddad Zavareh, Mehran Shokri, Arefeh Babazadeh, Mohsen Mohammadi, Hamed Mehdinezhad, Mahmoud Monadi, Parviz Amri Maleh, Hamid Reza Nouri, Abdolreza Daraei, Mahdie Yousefnia Pasha, Mehdi Tourani, Seyed Raheleh Ahmadian, Nadia Esmailzadeh, Seyyedeh Maedeh Mirtabar, Shakiba Asadi, Ebrahim Nasiraie, Nafiseh Ezami, Shahrbano Gorjinejad, Kobra Fallhpour, Fatemeh Fakhraie, Yousef Beheshti, Mahnaz Baghershiroodi, Faeze Rasti, Maryam Salehi, Atiyeh Aleahmad, Rahman Babapour, Rahim Malekzadeh, Rahmat Habibzadeh Kashi, and Yousef Yahyapour.
• Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
• Int. J. Clin. Pract. 2022 Jan 1; 2022: 1455708.

ObjectivesTo avoid worsening from mild, moderate, and severe diseases and to reduce mortality, it is necessary to identify the subpopulation that is more vulnerable to the development of COVID-19 unfavorable consequences. This study aims to investigate the demographic information, prevalence rates of common comorbidities among negative and positive real-time reverse-transcriptase polymerase chain reaction (rRT-PCR) patients, and the association between SARS-CoV-2 cycle threshold (Ct) at hospital admission, demographic data, and outcomes of the patients in a large population in Northern Iran.MethodsThis large retrospective cross-sectional study was performed from 7 March to 20 December 2020. Demographic data, including gender, age, underlying diseases, clinical outcomes, and Ct values, were obtained from 8,318 cases suspected of COVID-19, who were admitted to four teaching hospitals affiliated to Babol University of Medical Sciences (MUBABOL), in the north of Iran.ResultsSince 7 March 2020, the data were collected from 8,318 cases suspected of COVID-19 (48.5% female and 51.5% male) with a mean age of 53 ± 25.3 years. Among 8,318 suspected COVID-19 patients, 3,250 (39.1%) had a positive rRT-PCR result; 1,632 (50.2%) patients were male and 335 (10.3%) patients died during their hospital stay. The distribution of positive rRT-PCR revealed that most patients (464 (75.7%)) had a Ct between 21 and 30 (Group B).ConclusionElderly patients, lower Ct, patients having at least one comorbidity, and male cases were significantly associated with increased risk for COVID-19-related mortality. Moreover, mortality was significantly higher in patients with diabetes, kidney disease, and respiratory disease.Copyright © 2022 Farzin Sadeghi et al.

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