• Sevgi Bilgen, Dilek Erdoğan Ari, and Emel Özveri.
• Acibadem Kozyataği Hospital, Department of Anesthesiology, Ondokuz Mayıs Mah, Begonya Sokak, No. 12, Kadıköy, İstanbul, Turkey.
• Int. J. Clin. Pract. 2022 Jan 1; 2022: 73876007387600.

PurposeInvestigating the effect of ondansetron on the efficacy of tramadol in patients undergoing laparoscopic cholecystectomy.MethodsSixty American Society of Anesthesiologists (ASA) I-II patients over the age of 18 who underwent laparoscopic cholecystectomy were included in this study. All patients were given 1 mg/kg tramadol intravenously (iv) during the intraoperative period. Patients were randomly assigned to receive either 4 mg ondansetron (Group O) or 2 mL saline (Group S). Postoperative tramadol consumption, pain score (NRS), intensity of nausea (NRS), presence of vomiting, consumption of rescue analgesics and antiemetics, and patient satisfaction were recorded.ResultsA total of 60 patients were enrolled in the study; five patients were excluded due to deviation from the protocol. Data from 55 patients (Group O: 28 patients, Group S: 27 patients) were evaluated in the study. No differences between the two groups were detected for postoperative consumption of tramadol, pain score (NRS), intensity of nausea (NRS), presence of vomiting, consumption of rescue analgesics and antiemetics, and patient satisfaction.ConclusionsThe results showed that coadministration of tramadol and ondansetron did not change tramadol consumption during the postoperative 24 hours after laparoscopic cholecystectomy. Clinical trial registration number is as follows: https://clinicaltrials.gov/ct2/show/NCT04745273-01/31/2021.Copyright © 2022 Sevgi Bilgen et al.

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