• Shengyu Zhou, Fayan Zhang, Fangfang Chen, Peng Li, Yujie He, Julong Wu, Liang Dong, Chunting Wang, Ximing Wang, Wei Zhang, Wenqing Sun, Lixia Yin, Rumin Zhang, Jintong Zhao, and Baoxia Sun.
• Clinical Nursing Department, School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan, China.
• Int. J. Clin. Pract. 2022 Jan 1; 2022: 6498794.

AimTo explore the potential relationship between NLR and micronutrient deficiency in patients with severe COVID-19 infection.MethodsSixteen patients were categorized into the mild group (mild COVID-19) and severe group (severe COVID-19) based on the guideline of the management of COVID-19. The lactate dehydrogenase (LDH); superoxide dismutase (SOD), the inflammatory markers (neutrophil lymphocyte ratio (NLR)), erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), selenium (Se), iron (Fe), zinc (Zn), nickel (Ni), copper (Cu), chromium (Cr), cadmium (Cd), arsenic (As), and manganese (Mn) were measured in the blood.ResultsCompared to the mild group, the NLR (P < 0.05) and the level of Se (P < 0.01), Fe (P < 0.05), and Zn (P < 0.05) were significantly decreased in the severe group. The level of Se, Fe, and Zn was significantly correlated to NLR levels. Furthermore, close positive correlation was found between NLR and severity of COVID-19.ConclusionThe micronutrient deficiency in the blood is associated with NLR in the severity of COVID-19 patients.Copyright © 2022 Shengyu Zhou et al.

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