• Niyaz Mohammadzadeh Honarvar, Mahsa Samadi, Marzieh Seyedi Chimeh, Fatemeh Gholami, Niki Bahrampour, Mahmoud Jalali, Mohammad Effatpanah, Mir Saeid Yekaninejad, Mina Abdolahi, and Maryam Chamari.
• Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
• Int. J. Clin. Pract. 2022 Jan 1; 2022: 4836731.

MethodIn this double-blind, randomized, placebo-controlled trial, 75 children (aged 6-12) diagnosed with ADHD were randomly assigned into two groups. The supplementation group received vitamin D3 (2000 IU), and the control group received a placebo for 3 months. Blood samples were collected at baseline and after intervention to analyze the 25(OH)D, paraxonase-1 activity (PON-1), Total Antioxidant Capacity (TAC), and 8-isoprostan levels.ResultsA significant rise in circulating 25(OH)D was observed in the vitamin D group versus the placebo group at the end of the study. There was no reduction in 8-isoprostan levels in the vitamin D group compared to the placebo group. Serum paraxonase-1 and TAC concentration decreased in both groups, but these alterations were not statistically significant in the treatment group versus the placebo group at the end of the intervention.ConclusionVitamin D supplementation for 3 months did not have beneficial effects on biomarkers of oxidative stress status. To confirm these findings, further studies on children are suggested.Copyright © 2022 Niyaz Mohammadzadeh Honarvar et al.

10 keywords...

hide…