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- Ana Caroline Melo Dos Santos, Barbara Rayssa Correia Dos Santos, Bruna Brandão Dos Santos, Dhayane Magalhães Bastos, Edilson Leite de Moura, Abel Barbosa Lira Neto, Aline Cristine Pereira E Silva, Karol Fireman de Farias, de Medeiros AlvesVerônicaVDepartment of Nursing, Postgraduate Program in Nursing of the Federal University of Alagoas, Brazil., Antônio Egídio Nardi, and Elaine Virgínia Martins de Souza Figueiredo.
- Federal University of Alagoas, Biomarkers and Health Monitoring Research Group (BMS), Molecular Biology and Gene Expression Laboratory, Brazil; Biomarkers and Health Monitoring Research Group (BMS), Post-Graduate Program in Health Sciences, Federal University of Alagoas, Molecular Biology and Gene Expression Laboratory, Brazil.
- Neuroscience. 2022 Aug 21; 498: 280-288.
AbstractCytokines and nitric oxide have been associated with impulsive and aggressive personality traits. We conducted the first study that investigated the role of SNPs in cytokines and nitric oxide genes and the influence in the progression of aggressive and impulsive behavior in 107 of cocaine and crack users. In this case-control, IL-10 (-819C/T), TNFA (-308G/A) and ENOS (-786T/C) polymorphisms were determined by Real-Time PCR. In addition, the relationship between these polymorphisms and Impulsivity and Aggression was determined. We found that the physical aggressiveness sub score was negatively correlated with the C allele of -819C/T polymorphism of the IL-10 (b = -0.14; p = 0.04). The T allele of the SNP -786T/C of the ENOS gene positively predicts traits of physical aggressiveness (b = 0.14; p = 0.04). The GA genotype (b = 0.22; p = 0.01) and the A allele (b = 0.15; p = 0.02) of -308 G/A polymorphism of the TNFA were positively correlated with aggressiveness physical. The GA genotype (b = 0.20; p = 0.03) was positively correlated with aggressiveness verbal. IL-10 (-819C/T), TNFA (-308G/A) and ENOS (-786T/C) polymorphisms might be associated with high risk of aggressive and impulsive behavior.Copyright © 2022. Published by Elsevier Ltd.
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