• Neuroscience · Aug 2022

    NMDA receptor antagonist MK801 reduces dendritic spine density and stability in zebrafish pyramidal neurons.

    • Amanda Lamarca Dela Plata and Estuardo Robles.
    • Department of Biological Sciences and Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, USA.
    • Neuroscience. 2022 Aug 21; 498: 50-63.

    AbstractNMDA-type glutamate receptors play a critical role in activity-dependent neurite growth. We employed cell type-specific genetic labeling in zebrafish to examine the effects of NMDA receptor antagonism on the morphological development of tectal pyramidal neurons (PyrNs). Our data demonstrate that the NMDA receptor antagonist MK801 reduces PyrN spine density and stability without significantly altering dendritic growth and branching. However, the axons that synapse onto PyrN dendritic spines do exhibit reduced arbor growth and branching in response to MK801 treatment. Axons that synapse with PyrNs, but not on spines, are unaffected by MK801 treatment. These findings may reflect different roles for NMDARs during the development of spiny and aspiny dendrites.Copyright © 2022 IBRO. Published by Elsevier Ltd. All rights reserved.

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