• Shanshan Xue, Chuanmeng Zhang, Jie Xu, and Chenglin Zhou.
• Department of Clinical Laboratory, Taizhou People's Hospital, Affiliated 5 to Nantong University, Taizhou, Jiangsu Province, China.
• Medicine (Baltimore). 2022 Jun 24; 101 (25): e29203.

BackgroundCumulative evidence suggests that A-kinase interacting protein 1 (AKIP1) plays an important role in tumor progression. However, the prognostic value of AKIP1 expression in various cancers remains unclear. Here, we conducted a meta-analysis to evaluate the prognostic value of AKIP1 expression in patients with cancer.MethodsThe PubMed, Web of Science, EMBASE, CNKI, and Wanfang databases were systematically searched to identify studies in which the effect of AKIP1 expression on prognosis (overall survival or disease-free survival) was investigated. Hazard ratios (HRs) with 95% confidence intervals (CIs) were combined to assess the effect of AKIP1 expression on patient survival. Odds ratios (ORs) with 95% CIs were pooled to estimate the association between AKIP1 expression and clinicopathological characteristics of patients with cancer.ResultsNineteen eligible studies, encompassing 3979 patients, were included in the meta-analysis. AKIP1 expression was negatively associated with overall survival (HR = 1.86, 95% CI: 1.58-2.18, P < .001) and disease-free survival (HR = 1.69, 95% CI: 1.53-1.87, P < .001) in patients with cancer. Moreover, AKIP1 overexpression was positively correlated with adverse clinicopathological features, such as tumor size (OR = 2.22, 95% CI: 1.67-2.94, P < .001), clinical stage (OR = 2.05, 95% CI: 1.45-2.90, P < .001), depth of tumor invasion (OR = 2.98, 95% CI: 2.21-4.02, P < .001), and degree of lymph node metastasis (OR = 2.12, 95% CI: 1.75-2.57, P < .001).ConclusionsHigh AKIP1 expression is an unfavorable prognostic biomarker and may serve as a potential therapeutic target in patients with cancer.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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