• Tathiana Ghisi de Souza, Eduardo Bagne, Renata Mizani, Ali Abdalla Rotob, Rosa Estela Gazeta, Ana Laura de Sene Amâncio Zara, Cohorte Zika Virus Jundiaí, and Saulo Duarte Passos.
• Faculdade de Medicina de Jundiaí, Departamento de Pediatria, Jundiaí, SP, Brazil.
• Medicine (Baltimore). 2022 Jun 24; 101 (25): e29488.

AbstractThe Hammersmith infant neurological examination (HINE) is a highly predictive tool for the easy and low-cost detection of cerebral palsy. Between 2015 and 2016, the rapid spread of the Zika virus (ZIKV) in Brazil was responsible for an increase in microcephaly cases. This study aimed to verify the accuracy of the HINE for the early detection of neurological problems in Brazilian babies exposed to ZIKV.This was a cross sectional case-control study of children exposed to ZIKV. This study was part of the Jundiaí ZIKV Cohort. Of a total sample of 782 children, 98 were evaluated (26 in the exposed group and 63 in the control group). We included late preterm infants and term infants who were exposed to the ZIKV and were participants in the ZIKV Cohort study. Student's t-test and stepwise multivariate logistic regression were used to compare groups.Of the 26 items evaluated in the five scored categories of the HINE (cranial nerve function, posture, movements, tone, reflexes, and reactions), only the difference in ankle dorsiflexion between the exposed and the control groups was statistically significant. However, some items showed a significant trend in relation to the control group.Our results demonstrated the importance of early neurological assessment of infants exposed to ZIKV, even in those without a microcephaly diagnosis.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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