• Acta clinica Croatica · Dec 2021

    MATERNAL GUT MICROBIOTA IN PREGNANCIES RESULTING IN DOWN SYNDROME NEWBORNS - A PILOT STUDY.

    • Mehmet Hursitoglu, Alev Kural, Sibel Kuras, Esra Akdeniz, Salim Sezer, Sema Suzen Caypinar, Cemal Kazezoglu, Bulent Yaprak, Faruk Karandere, and Hamit Zafer Guven.
    • 1Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 2Internal Medicine Department, Basaksehir Cam & Sakura Hospital, University of Health Sciences, Istanbul, Turkey; 3Biochemistry Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 4Biochemistry Department, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, Turkey; 5Department of Medical Education, Marmara Medical Faculty, Marmara University, Istanbul, Turkey; 6Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 7Biochemistry Department, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; 8Gynecology and Obstetrics Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.
    • Acta Clin Croat. 2021 Dec 1; 60 (4): 722-730.

    AbstractDown syndrome (DS) is one of the main genetic abnormalities of newborns. Therefore, prenatal diagnosis of this syndrome is of paramount importance to the family and the community. The microbiota system is important in early brain development. We tried to study and compare gut microbiota (GM) composition in pregnancies that resulted in DS neonates with pregnancies that resulted in healthy children. The study population consisted of 21 pregnant women having delivered DS newborns (group 1) and 22 pregnant women who had given birth to healthy newborns (group 2). The GM composition was determined and compared between the two groups. There were no significant age and gestational age differences between the two groups (p>0.005 both). Regarding GM analysis, microorganisms of the families Clostridiaceae and Pasteurellaceae were more abundant in the group of women having delivered DS neonates than the group of women having delivered healthy newborns (p<0.05). The results of our pilot study showed that the GM system might have a role in the pathophysiology of DS. The GM changes may be used in the prenatal diagnosis and prevention of this syndrome. Further studies are needed in this field.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…