• Anna Luiza Silva Almeida Vicente, Alessandra Bernadete Trovó de Marqui, Mariana Kefalas Oliveira Gomes, Alan Vinicius Assunção-Luiz, Marly Aparecida Spadotto Balarin, Sarah Cristina Sato Vaz Tanaka, Elisabete Aparecida Mantovani Rodrigues de Resende, Marco Fábio Prata Lima, and Mariangela Torreglosa Ruiz Cintra.
• Hospital de Câncer de Barretos - Barretos (SP), Brazil.
• Rev Assoc Med Bras (1992). 2022 Jan 1; 68 (6): 785-791.

ObjectiveThe polycystic ovary syndrome is the most common endocrine disorder, characterized by the dysregulation of ovarian angiogenesis. This alteration can be related to changes in the activities of the vascular endothelial growth factor (VEGF) gene. Single-nucleotide polymorphisms have been observed in the promoter, intronic, and untranslated regions of the VEGF gene, and several studies have suggested that these polymorphisms may be associated with the risk of polycystic ovary syndrome. This study aimed to investigate the association between rs2010963 and rs833061 polymorphisms and haplotypes of VEGF in the etiology of polycystic ovary syndrome.MethodsA total of 210 women, 102 diagnosed with polycystic ovary syndrome and 108 controls, participated in this study. The genotyping of the samples was performed by PCR-RFLP and real-time PCR for rs2010963 and rs833061 polymorphisms, respectively. The statistical analyses were performed by the chi-square test and logistic regression model.ResultsThe clinical characteristics of the patients showed that 75.8% of the patients did not become pregnant, 36.3% had a family history of polycystic ovary syndrome, 58.6% were obese, and about 60% had clinical characteristics of hyperandrogenism. There were no associations between the distribution of rs2010963 (OR 1.24; 95%CI 0.60-2.57; p=0.56) and rs833061 (OR 0.78; 95%CI 0.32-1.92; p=0.59) in patients and controls.ConclusionsThe patients with polycystic ovary syndrome have similar rates of VEGF polymorphisms rs2010963 and rs833061 on the general population.

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