• Xiaoyun Sun, Yuping He, Zhuoping Shen, and Li Chen.
• Department of Neurology, Zhuji People's Hospital, Zhejiang Province, China.
• J Coll Physicians Surg Pak. 2022 Jul 1; 32 (7): 860-863.

ObjectiveTo analyse relationship between tumour necrosis factor-α (TNF-α) (G308A) polymorphism and Vascular Parkinson (VP) complicated with pulmonary infection.Study DesignAnalytical study.Place And Duration Of StudyZhuji people's Hospital, China, from February 2017 to April 2021.MethodologyEighty five patients with VP complicated with pulmonary infection were included in the observation group. Eighty five patients with VP were included in the comparison group. Genotypic analysis of TNF-α (G308A) and serum TNF-α were detected.ResultsTNF-α (G308A) polymorphism in both the observation group and control group conformed to the genetic balance rule by the Hardy-Weinberg test. The frequency of each gene satisfied the genetic balance (p=0.175, and p=0.184, respectively). Genotype distribution and alleles of TNF-α (G308A) between the observation group and the control group were different (both p <0.001). Compared with control group, serum TNF-α level in the observation group was higher (p <0.001). In the observation group, serum TNF-α level in cases with GA+AA genotype (carrying A allele) was higher than that in cases with GG genotype (non A allele) (p <0.001).ConclusionTNF-α (G308A) polymorphism is associated with VP complicated with pulmonary infection. VP Patients with TNF-α (G308A) AA genotype and an allele may have a high risk of pulmonary infection.Key WordsTumor necrosis factor-α (TNF-α), Polymorphism, Vascular Parkinson (VP), Pulmonary infection.

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